The Dehghani Lab

This lab is interested in understanding the nuclear and chromatin organization of pluripotency. Models of pluripotency include preimplantation and early postimplantation stages of mammalian development and chicken primordial germ cells. Chromatin and nuclear organization have a central role in the control of transcription, and thus may significantly contribute to the regulation of differentiation. States of differentiation and function of the nucleus and chromatin can be regulated by many different intracellular signaling pathways. Nuclear sub-structures including PML nuclear bodies (PML NBs) may be the sites of convergence for many intracellular signaling pathways, where arms of regulation could be originated from.

To study the epigenetic roleplayers of pluripotency
To identify the epigenetic effects of chromatin organization on nuclear functions
To understand the role of PML NBs in pluripotency, apoptosis and cellular defence
To generate in vitro states of nuclear activity that promote transgenesis

Department of Basic Science
Faculty of Veterinary Medicine
AND
Embryonic and Stem Cell Biology and Biotechnology
Research Group, Institute of Biotechnology

University pardis, Azadi Square, Mashhad, Iran
91779-48974 P.O. Box: 1793
+98-511-880-3763 (Tel), +98-511-876-3852 (fax)
dehghani@um.ac.ir